Detailed view for LOAG_03725

Basic information

TDR Targets ID: 951453
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 6.4283 | Length (AA): 871 | MW (Da): 99263 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0031931   TORC1 complex  
GO:0031929   TOR signaling pathway  
GO:0005515   protein binding  
GO:0005488   binding  

Metabolic Pathways

mTOR signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 865 5wbi (A) 549 1336 27.00 0 1 0.644563 1.69
7 167 1un0 (A) 96 248 12.00 0 0.98 0.440445 -1.08
24 159 4hxt (A) 105 237 17.00 0 0.9 0.452742 -0.78
35 124 1xqr (A) 123 223 38.00 0.45 0.6 0.13503 0.8

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128380)

Species Accession Gene Product
Arabidopsis thaliana AT5G01770   regulatory-associated protein of TOR 2
Arabidopsis thaliana AT3G08850   Regulatory-associated protein of TOR 1
Brugia malayi Bm1_20705   hypothetical protein
Candida albicans CaO19.8048   weak similarity to CDC39, WD-40 domain
Candida albicans CaO19.418   weak similarity to CDC39, WD-40 domain
Caenorhabditis elegans CELE_C10C5.6   Protein DAF-15, isoform B
Dictyostelium discoideum DDB_G0270398   HEAT repeat-containing protein
Drosophila melanogaster Dmel_CG4320   CG4320 gene product from transcript CG4320-RC
Echinococcus granulosus EgrG_001141100   regulatory associated protein of mTOR
Entamoeba histolytica EHI_040260   HEAT repeat domain containing protein
Echinococcus multilocularis EmuJ_001141100   regulatory associated protein of mTOR
Homo sapiens ENSG00000141564   regulatory associated protein of MTOR, complex 1
Leishmania braziliensis LbrM.25.2140   hypothetical protein, conserved
Leishmania infantum LinJ.25.0620   hypothetical protein, conserved
Leishmania major LmjF.25.0610   hypothetical protein, conserved
Leishmania mexicana LmxM.25.0610   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_03725   hypothetical protein
Loa Loa (eye worm) LOAG_03502   hypothetical protein
Mus musculus ENSMUSG00000025583   regulatory associated protein of MTOR, complex 1
Oryza sativa 4351289   Os12g0110000
Oryza sativa 9266997   Os11g0109933
Saccharomyces cerevisiae YHR186C   Kog1p
Schistosoma japonicum Sjp_0102140   Regulatory-associated protein of mTOR, putative
Schistosoma japonicum Sjp_0032410   ko:K07204 regulatory associated protein of mTOR, putative
Schistosoma mansoni Smp_159000   hypothetical protein
Schmidtea mediterranea mk4.000569.09   Regulatory-associated protein of mTOR
Schmidtea mediterranea mk4.000424.03  
Schmidtea mediterranea mk4.000569.10  
Schmidtea mediterranea mk4.000569.06  
Schmidtea mediterranea mk4.000569.08   Regulatory-associated protein of mTOR
Trypanosoma brucei gambiense Tbg972.11.600   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.620   Regulatory-associated protein of TOR1
Trypanosoma cruzi TcCLB.506925.30   Regulatory-associated protein of TOR1
Trichomonas vaginalis TVAG_064730   conserved hypothetical protein
Trichomonas vaginalis TVAG_468260   conserved hypothetical protein
Trichomonas vaginalis TVAG_282820   conserved hypothetical protein
Trichomonas vaginalis TVAG_423460   conserved hypothetical protein
Trichomonas vaginalis TVAG_432270   conserved hypothetical protein
Trichomonas vaginalis TVAG_064720   conserved hypothetical protein
Trichomonas vaginalis TVAG_058190   conserved hypothetical protein
Trichomonas vaginalis TVAG_097890   conserved hypothetical protein

Essentiality

LOAG_03725 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.03.0460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.03.0460 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.03.0460 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.03.0460 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
YHR186C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LOAG_03725 (Loa Loa (eye worm)), hypothetical protein
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